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The Hour That Was Never Written

You do not forget an operation. There is nothing there to forget — the hour was never recorded in the first place, and that was the intention.

A gap, not a blur

People describe it the same way almost every time. They remember the ceiling tiles. They remember somebody saying "you might feel a bit cold going in". And then they are in a different room, wrapped in a warm blanket, with three hours missing and no sense of having spent them.

What is striking is the quality of the absence. It is not like forgetting a name, where you know there is something there and cannot reach it. It is not like a hazy night, where fragments surface later. There is no edge to feel around. The time is simply not represented.

That is because nothing was forgotten. Forgetting means losing hold of something you once had. Here, no record was ever made.

Amnesia is the goal, not the side effect

This is the part that surprises most people: not remembering is not an unfortunate consequence of anesthesia. It is one of the things anesthesia is for.

General anesthesia is usually described as several separable effects produced together — unconsciousness, loss of memory formation, stillness, and the blunting of the body's response to being operated on.1 They are listed separately because they can be produced separately, by different drugs, in different amounts. An anesthetist is not simply turning a dial marked "asleep". They are arranging several things at once, and one of them is making sure you do not lay down a record of the next few hours.

The gap in your memory is not damage. It is the intended result, delivered on purpose, by someone who was watching a monitor the whole time.

Put that way it sounds unsettling, and then you think about what the alternative would be — a complete and retrievable memory of surgery — and it stops sounding unsettling very quickly.

Awake, talking, and not recording

The clearest demonstration that memory and consciousness are different switches comes from sedation rather than full anesthesia.

Drugs such as midazolam produce dense memory loss at doses well below those that would put anybody under.2 People given them for a procedure are frequently awake throughout. They answer questions. They follow instructions. They make jokes, occasionally better ones than usual. They are, by every outward measure, present.

And afterwards they remember none of it. Not dimly — not at all. Relatives find this genuinely disconcerting: you held a lucid conversation with someone who has since been issued no copy of it.

It settles something that is otherwise hard to see. Being conscious of a moment and keeping a moment are two separate operations, and you can have the first without the second. For most of a life they run together so reliably that it never occurs to anyone that they are different jobs.

Where in the brain this happens

Most of the drugs involved — propofol, etomidate, the inhaled agents, the benzodiazepines — work largely by enhancing the brain's main inhibitory signal, acting at what are called GABAA receptors. The effect is to quieten things down. But the quietening is not uniform, and the hippocampus, which is essential to forming new memories of events, turns out to be particularly sensitive.

The evidence has got quite specific. Work in Beverley Orser's laboratory found that a particular subtype of GABAA receptor concentrated in the hippocampus — those containing the α5 subunit — mediates the memory-blocking effect of etomidate, while leaving its sedative effect intact.3 Different receptors, different jobs. The amnesia and the sleepiness can be pulled apart at the molecular level, which is a rather striking confirmation of what the sedation story suggests from the outside.

There is a second half to it. Turning an experience into a lasting memory is not instantaneous; it depends on patterned activity in the hippocampus continuing after the event itself. Suppress that activity and even an experience that registered at the time has nothing to consolidate it. The event happens. The writing-down does not.

Being honest about the edges

Two things deserve stating plainly rather than being tidied away.

The first is that awareness during general anesthesia does happen. It is rare, it is taken extremely seriously by the profession, and a great deal of effort goes into monitoring for it — but "rare" is not "never", and people who have experienced it deserve better than being told it is impossible.4

The second is that questions about longer-term thinking and memory after surgery — particularly in older patients — are an active and genuinely unsettled area of research. The terminology itself was overhauled in 2018 precisely because the field had been talking past itself.5 Disentangling the effects of the anesthetic from the effects of major surgery, inflammation, pain, disrupted sleep and being unwell in the first place is hard, and anyone claiming the matter is settled in either direction is ahead of the evidence.

This article is about how memory works, not advice about anybody's operation. The people to ask about that are the ones holding the chart.

What the gap is good for

There is something clarifying about a few hours that were never written down.

Most of the time it is possible to believe that experience records itself — that living through something is the same act as keeping it. Anesthesia separates the two cleanly and shows you the join. You were there. You were, for part of it, talking. And none of it was kept, because the keeping is a separate process that was switched off.

Which is worth remembering about the ordinary days too. They are not being recorded either, just more slowly and with less supervision. The difference between a day you still have in twenty years and a day that is simply gone is very often whether anyone wrote anything down.

"The memorial for someone named Daniel... would you like to get to know what kind of man he was?"

References

  1. Brown, E. N., Lydic, R., & Schiff, N. D. (2010). General anesthesia, sleep, and coma. New England Journal of Medicine, 363(27), 2638–2650.
  2. Veselis, R. A., Reinsel, R. A., Feshchenko, V. A., & Wronski, M. (1997). The comparative amnestic effects of midazolam, propofol, thiopental, and fentanyl at equisedative concentrations. Anesthesiology, 87(4), 749–764.
  3. Cheng, V. Y., Martin, L. J., Elliott, E. M., et al. (2006). α5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate. Journal of Neuroscience, 26(14), 3713–3720.
  4. Mashour, G. A., & Avidan, M. S. (2015). Intraoperative awareness: Controversies and non-controversies. British Journal of Anaesthesia, 115(suppl 1), i20–i26.
  5. Evered, L., Silbert, B., Knopman, D. S., et al. (2018). Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery. Anesthesiology, 129(5), 872–879.

Written as an explanation of how memory formation works, not as medical advice. Questions about your own anesthetic belong with your anesthetist or surgeon.